什么是 Harness Engineering，为什么最近都在说它

Cancer immunotherapy harnesses and amplifies the host's anti-tumor immune responses to eradicate malignant cells. Tumor neoantigens serve as ideal targets due to high specificity and immunogenicity. Circular RNA (circRNA), with a stable covalently closed structure, can be engineered as a novel vector for neoantigen expression. Here, we developed a circRNA-based vaccine encoding multiple melanoma neoantigens (circRNA

Hydrogen spillover has long been recognized as a ubiquitous phenomenon in heterogeneous catalysis, yet its rational utilization has been hindered by the lack of design principles accounting for its support dependence. The present work demonstrates that support-dependent hydrogen spillover can be harnessed to promote Ni-based CO

Biological photosynthesis harnesses multiple visible light photons to drive thermodynamically demanding reactions, whereas realizing analogous multi-photon excitation in artificial photosynthesis remains challenging. Inspired by enzymatic cascades, we herein report a host-guest supramolecular approach to boosting consecutive multi-photon excitation (>2 photons) by confining a 9-mesityl-10-methylacridinium perchlorate (Acr