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Continuing versus Withholding renin angiotensin aldosterone system antagonists before non-cardiac surgery: A protocol of a systematic review and meta-analysis.

Perioperative use of ACE inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) has been linked to early postinduction hypotension requiring vasopressor use under general anesthesia, potentially leading to complications like acute renal injury, myocardial injury, or stroke. However, the relationship between perioperative ACEI/ARB use and major morbidity remains uncertain.
www.ncbi.nlm.nih.gov

Closed-loop and Artificial intelligence guided cardiopulmonary resuscitation using real-time physiological signals: a systematic review and meta-analysis.

Current cardiopulmonary resuscitation (CPR) includes breaks to check rhythm and pulse, while high-quality CPR requires continual chest compressions. Artificial intelligence (AI)-driven "closed-loop" or "near-closed-loop" systems may evaluate CPR-contaminated signals, guide shock and pulse decisions.
www.ncbi.nlm.nih.gov

Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice.

Glioblastoma (GBM) is an aggressive primary malignant brain tumor in adults with a median patient survival of 12-18 months post-diagnosis, and no effective treatments, to date. The PI3K/Akt and Wnt/β-catenin signaling pathways promote GBM cell growth, survival, invasiveness and therapeutic resistance. We hypothesize that inhibiting Akt and β-catenin, which are central regulatory proteins of the PI3K/Akt and Wnt/β-catenin pathway, will suppress GBM growth and progression.
www.ncbi.nlm.nih.gov

Optic nerve head microcirculation on optical coherence tomography angiography is reduced in systemic lupus erythematosus and relates to nailfold videocapillaroscopy phenotypes: a cross-sectional case-control study.

To quantify ocular microcirculation by optical coherence tomography angiography (OCTA) and peripheral microcirculation by nailfold videocapillaroscopy (NVC) in systemic lupus erythematosus (SLE), to compare OCTA/optical coherence tomography (OCT) metrics with healthy controls, and to explore NVC-ocular relationships.
www.ncbi.nlm.nih.gov
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