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Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase

Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligase. - Howard S, Amin N, Benowitz AB, Chiarparin E, Cui H, Deng X, Heightman TD, Holmes DJ, Hopkins A, Huang J, Jin Q, Kreatsoulas C, Martin ACL, Massey F, McCloskey L, Mortenson PN, Pathuri P, Tisi D, Williams PA ACS Med Chem Lett (4) 1208-12 (2013)
www.ebi.ac.uk

Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase

Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligase. - Howard S, Amin N, Benowitz AB, Chiarparin E, Cui H, Deng X, Heightman TD, Holmes DJ, Hopkins A, Huang J, Jin Q, Kreatsoulas C, Martin ACL, Massey F, McCloskey L, Mortenson PN, Pathuri P, Tisi D, Williams PA ACS Med Chem Lett (4) 1208-12 (2013)
www.ebi.ac.uk

TEV Cleaved Human ATP Citrate Lyase Bound to 4S Hydroxycitrate

Binding of hydroxycitrate to human ATP-citrate lyase. - Hu J, Fraser ME Acta Crystallogr D Struct Biol (73) 660-671 (2017)
www.ebi.ac.uk

Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.

Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. - Verschueren KHG, Verstraete K Nat Struct Mol Biol (28) 636-638 (2021)
www.ebi.ac.uk

Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH in space group C2221

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. - Verstraete K, Verschueren K Nature (568) 571-575 (2019)
www.ebi.ac.uk

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