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Injectable Hydrogels Composed of Thiolated Chitosan, Silk Fibroin, and Gallium-Doped Bioactive Glass Nanoparticles for Bone Regeneration and Osteosarcoma Suppression.

The repair and reconstruction of bone defects resulting from tumor-related bone resection surgery face significant challenges. Developing biomaterials with dual functions of tumor therapy and bone regeneration is a promising strategy for osteosarcoma treatment.
www.ncbi.nlm.nih.gov

Quick Guides for Use of the CompOSE Data Base

We present a combination of two quick guides aimed at summarizing relevant information about the CompOSE nuclear equation of state repository. The first is aimed at nuclear physicists and describes how to provide standard equation of state tables. The second quick guide is meant for users and describes the basic procedures to obtain customized tables with equation of state data. Several examples are included to help providers and users to understand and benefit from the CompOSE database.
arxiv.org

Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells.

The frontotemporal dementia-linked S320F mutation in the microtubule-associated protein tau promotes spontaneous aggregation, yet the structural basis of its amyloidogenesis remains unclear. Using cryo-electron microscopy, we determined the structure of an S320F
www.ncbi.nlm.nih.gov

Structural basis of receptor retro-translocation in peroxisomal protein import.

Peroxisomes import all matrix proteins post-translationally from the cytosol, a process that requires recycling of cargo receptors across the peroxisomal membrane. The membrane-embedded ubiquitin ligase, composed of Pex2, Pex10, and Pex12, is central to this process, but its mechanism remains unclear. Here we determined cryo-electron microscopy structures of the
www.ncbi.nlm.nih.gov