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CSF Proteins Associated With Neuroaxonal Damage in Early Active Multiple Sclerosis.

The aim of this study was to identify biological processes associated with neuroaxonal degeneration in multiple sclerosis (MS) by analyzing protein patterns linked to neurofilament light (NfL) protein in CSF and serum samples.
www.ncbi.nlm.nih.gov

Multitarget mechanisms of Origanum vulgare L. essential oil against clinically isolated carbapenem-resistant Acinetobacter baumannii.

Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a threat to the treatment of infectious diseases. The efficacy of Origanum vulgare L. essential oil (OEO) and its primary components, carvacrol (CAR) and thymol (THY), against clinical CRAB isolates,was evaluated.
www.ncbi.nlm.nih.gov

Psychological and hematological factors associated with fatigue in patients with Crohn's disease receiving pharmacological treatment.

Fatigue is debilitating and costly for patients with Crohn's disease (CD) and the healthcare system. Thus, as there are no well-established therapies for fatigue in patients with CD, it is essential to investigate its risk factors and collaborate to prevent or reduce its burden.
www.ncbi.nlm.nih.gov

Opioid-induced neurotoxicity after opioid conversion to methadone in patients with cancer pain using the stop-and-go method: A multicenter retrospective cohort study.

To describe the frequency of opioid-induced neurotoxicity (OINT) after opioid conversion (OC) to methadone using the Stop-and-Go (SAG) method in cancer patients with inadequate pain control, and to identify factors associated with OINT.
www.ncbi.nlm.nih.gov

Augmenter of Liver Regeneration Enhances Hepatocellular Carcinoma Cell Growth Through COX-2-associated Signaling.

The expression of augmenter of liver regeneration (ALR), a potent growth factor, is significantly up-regulated in hepatocellular carcinoma (HCC). This study aims to investigate the potential functions and mechanisms of ALR in HCC.
www.ncbi.nlm.nih.gov

Age-dependent diagnostic and treatment response prediction of TBII and TSI in Graves' orbitopathy: integration with orbital MRI biomarkers.

Thyrotropin-binding inhibitory immunoglobulin (TBII) is involved in the pathogenesis of Graves' orbitopathy (GO). Although thyroid-stimulating immunoglobulin (TSI) may offer superior diagnostic or prognostic value, its utility remains incompletely defined.
www.ncbi.nlm.nih.gov

Exploratory Single-Cell Transcriptomic Profiling Reveals Dysregulated Glial Populations and Pathways in Focal Cortical Dysplasia Epilepsy.

Focal cortical dysplasia (FCD) is a prevalent cause of drug-resistant epilepsy, but a comprehensive understanding of its pathogenesis at a cellular resolution remains limited. Previous transcriptomic studies, often constrained by bulk tissue analysis, have been unable to dissect the cell-type-specific contributions to epileptogenesis.
www.ncbi.nlm.nih.gov

Fabrication of ultrathin flexible microwave shielding absorbers based on OA-γ-Fe

To break through the performance bottlenecks of electromagnetic protection materials in terms of lightweight design, broadband absorption, and multifunctional integration, this work proposes a synergistic design strategy based on magneto-dielectric coupled absorbing units and periodic micro-circular array superstructures. At the microscopic scale, oleic acid (OA)-modified γ-Fe
www.ncbi.nlm.nih.gov

Drug-related pressure ulcers in hospitalised patients: a multicentre retrospective study in Japan identifying high-risk medications and patient characteristics.

To characterise patient and medication-related patterns observed in drug-related pressure ulcers (DRPUs) and provide descriptive findings that may support future consensus-building.
www.ncbi.nlm.nih.gov

Early Detection of Asthma: Exploring Inflammatory Biomarkers in Symptomatic Adults with Normal Spirometry.

We previously showed that individuals without a prior history of asthma, presenting with unexplained respiratory symptoms and normal spirometry, may exhibit airway hyperresponsiveness and underlying eosinophilic (T2) inflammation, features suggestive of undiagnosed early-stage asthma. Improving our understanding of the inflammatory processes that contribute to asthma onset is essential, as it may ultimately lead to earlier detection, timely intervention and improved long-term outcomes.
www.ncbi.nlm.nih.gov