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The repair and reconstruction of bone defects resulting from tumor-related bone resection surgery face significant challenges. Developing biomaterials with dual functions of tumor therapy and bone regeneration is a promising strategy for osteosarcoma treatment.

The frontotemporal dementia-linked S320F mutation in the microtubule-associated protein tau promotes spontaneous aggregation, yet the structural basis of its amyloidogenesis remains unclear. Using cryo-electron microscopy, we determined the structure of an S320F

Peroxisomes import all matrix proteins post-translationally from the cytosol, a process that requires recycling of cargo receptors across the peroxisomal membrane. The membrane-embedded ubiquitin ligase, composed of Pex2, Pex10, and Pex12, is central to this process, but its mechanism remains unclear. Here we determined cryo-electron microscopy structures of the

2016年底中国移动提出了在现有综合业务接入区建设基础上进行微网格规划，对综合业务接入区网络进行逐步的划小，缩短各分纤点接入距离，丰富现有网络，通过微网格建设，充分利用综合业务接入区内分纤点、接入主干光缆等各类资源，实现各类业务的高效接入，夯实全业务运营网络基础。