AI Agent 几种架构模式

Medication adherence is central to evaluating treatment effectiveness, reducing preventable complications, and informing value-based care. The proportion of days covered (PDC) is widely used but inconsistently calculated across studies because of variations in data sources and methods. Prescription timestamps (written, filled, and sold) capture different stages of the medication journey; however, their impact on adherence measures has not been systematically compared.

This retrospective study was to identify the outcomes and safety of anlotinib combined with PD-1 blockades in patients with metastatic esophageal squamous cell carcinoma (ESCC).

In this study, a series of novel thiadiazole derivatives (7a, 7b, 9a, 9b, and 9c) were rationally designed as potential VEGFR-2 inhibitors using a pharmacophore-guided strategy. The compounds were synthesized and assessed for their antiangiogenic and anticancer effects. Among them, compound 9b showed the strongest VEGFR-2 inhibition (IC