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RNA Sequencing of Sepsis Patients Informs Tests to Quickly Diagnose Pathogens and Resistance.

Diagnosis of infection in patients with sepsis takes days via culture, and appropriate treatment of pathogens is delayed awaiting results. We hypothesize that we can use RNA sequencing from patients with sepsis to identify novel targets for faster nucleic acid-based tests.
www.ncbi.nlm.nih.gov

Fanconi anemia complementation group C gene (FANCC) association with hereditary and sporadic renal tumors.

Inactivating genomic alterations (GA) of the FANCC gene are associated with genomic instability, DNA cross-linking, and homologous DNA repair deficiency. Here, we evaluated the incidence of FANCC GA in renal tumors (RT).
www.ncbi.nlm.nih.gov

Pelvic organ prolapse burden on sexual health and body image: a cross-sectional study.

Pelvic organ prolapse (POP) is common and can affect sexual health and body image. Sexual concerns of non-sexually active (NSA) females with POP have been poorly described.
www.ncbi.nlm.nih.gov

HOPE for children: successful pediatric DCD heart transplantation using hypothermic oxygenated perfusion.

The number of children referred for advanced heart failure management is increasing and with it the demand for heart transplant. However, transplantation rates have declined and waiting list mortality is up to 25%. While donation after circulatory death (DCD) heart recovery has increased adult transplant activity significantly, barriers have prevented the same in pediatrics. In the UK and Belgium, we have adopted hypothermic oxygenated perfusion (HOPE) to address this inequity.
www.ncbi.nlm.nih.gov

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onlinelibrary.wiley.com

Late referrals and high mortality in tricuspid regurgitation: a call for timely intervention.

Tricuspid regurgitation (TR) is associated with increased morbidity and mortality. The optimal timing for referral and intervention remains uncertain. To evaluate outcomes in patients with TR referred for tricuspid valve intervention.
www.ncbi.nlm.nih.gov