chandra

Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors. - Subramanya HS, Chandra RB, Ashok KN, Chakshusmathi G, Ramesh KS ACS Med Chem Lett (4) 1152-7 (2013)

The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. - Schumacher MA Nat Commun (9) 1139 (2018)

Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. - Kim D, Huang P, Rastinejad F, Khorasanizadeh S Nat Struct Mol Biol (17) 1027-9 (2010)

Large collections of knockout organisms facilitate the elucidation of gene functions. Here we used retroviral insertion or homologous recombination to disrupt 472 genes encoding secreted and membrane proteins in mice, providing a resource for studying a large fraction of this important class of drug target. The knockout mice were subjected to a systematic phenotypic screen designed to uncover alterations in embryonic development, metabolism, the immune system, the nervous system and the cardiova