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Metabolic flexibility following resistance exercise and a high protein diet in older men: Results from a 12-week randomized controlled trial.

Aging and sarcopenia are associated with metabolic inflexibility. This study investigated the effects of resistance exercise (RE) and a high protein diet (PRO) on metabolic flexibility (the ability to adjust rates of substrate oxidation to changes in fuel availability) in older men.
www.ncbi.nlm.nih.gov

The longitudinal mechanism of alexithymia and social cognition influencing depression: Based on cross-lagged panel network analysis and structural equation model.

Alexithymia and social cognitive deficits may be the risk factors of depression. Guided by the cognitive-development theory of emotional awareness, this study aims to construct an integrated framework to elucidate the dynamic relationships among alexithymia, social cognition and depression at the dimensional level.
www.ncbi.nlm.nih.gov

Robo2-Nrxn3 Deficiency: A Molecular Hub Linking Excitation-Inhibition Imbalance to the Pathogenesis of Schizophrenia.

Schizophrenia (SZ) is characterized by excitation-inhibition (E-I) imbalance as a core pathophysiological feature, but its molecular underpinnings remain elusive. Susceptibility gene Roundabout2 (Robo2), which regulates E-I balance in the central nervous system, may play a critical role in the pathogenesis of SZ by contributing to this dysregulation.
www.ncbi.nlm.nih.gov

Soluble α2δ-1, altered in disease CSF, modulates network homeostasis and rescues deficits in a neuropsychiatric mouse model.

Excitation-inhibition (E/I) balance depends on dynamic communication between neuronal subtypes, potentially beyond classical neurotransmission. While membrane-bound ion channels are essential for neuronal function, their potential roles as extracellular regulators of network dynamics remain largely unexplored. Here, we identify a soluble form of the voltage-gated Ca
www.ncbi.nlm.nih.gov