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pnas journal

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Welcome, PNAS Nexus!

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Large language models are homogeneously creative.

Numerous large language models (LLMs) are marketed for use as creativity support tools, despite several studies showing that using an LLM as a creative partner narrows creative outputs. However, these studies only consider the effects of interacting with a single LLM on specific creativity tasks, begging the question of whether narrowed creativity stems from using a particular LLM-with an arguably limited range of outputs-or from using LLMs
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Cellular senescence in neurodegenerative diseases: a bibliometric analysis and mechanistic synthesis linking translational pathways to therapeutic implications.

Cellular senescence is now recognized as a pivotal driver of neurodegenerative diseases (NDs). Despite advances in understanding senescence mechanisms, such as the p16
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Introducing PNAS Nexus

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Polypharmacology of S-1117, an Fc-fused IgG-selective degrading enzyme, for chronic treatment of autoantibody-mediated diseases.

Antigen-specific immunoglobulin-G (IgG) antibodies cause or contribute to the pathogenesis of a wide spectrum of human diseases and conditions. Multiple therapeutic approaches have been developed, yet they are limited by variable safety and efficacy, patient inconvenience, and cost. IdeS, a cysteine protease derived from
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